PF-4800567

SKU: orb1302133

Description

PF-4800567

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1188296-52-7
• MW: 359.81
• Purity: 99.74%
• Formula: C₁₇H₁₈ClN₅O₂
• SMILES: Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1
• Target: Casein Kinase
• Solubility: DMSO:60 mg/mL (166.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM)

Bioactivity

• Target IC50:
  CK1ε:32 nM|CKIδ:711 nM
• In Vivo:
  PF-4800567 (100 mg/kg, s.c.) is quickly absorbed and distributed in the plasma and brain of mice.
• In Vitro:
  PF-4800567 shows inhibitory activity against CK1ε and CK1δ in whole cells, with IC50 of 2.65 and 20.38 μM, respectively PF-4800567 (0.01-10 μM) blocks CK1-mediated PER3 nuclear localization mediated by CK1 and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 (32 nM) has little effect o the circadian clock.

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CK1ε, CaseinKinase, Casein Kinase, inhibit, Inhibitor, PF 4800567, PF-4800567, PF4800567

Compound Identifiers

PubChem CID

53472153