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PF-4136309

SKU: orb1304209

Description

PF-4136309 (INCB8761) is a potent, selective, and orally active antagonist of the CCR2 chemokine receptor. It is a valuable research tool for investigating CCR2-mediated pathways in inflammatory and metabolic diseases, as demonstrated in both cellular assays and animal models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1341224-83-6
MW568.60
Purity>98%
FormulaC29H31F3N6O3
SMILES[H][C@@]1(CC[C@](O)(CC1)c1ccc(cn1)-c1ncccn1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F
TargetGPCR
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

Target IC50
CCR2 (mouse):17 nM|CCR2 (human):5.2 nM|CCR2 (rat):13 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

INCB8761

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

PF-4136309 (orb1304209)

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5 mg
$ 210.00
25 mg
$ 460.00
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