PF-4136309

SKU: orb1304209

Description

PF-4136309 (INCB8761) is a potent, selective, and orally active antagonist of the CCR2 chemokine receptor. It is a valuable research tool for investigating CCR2-mediated pathways in inflammatory and metabolic diseases, as demonstrated in both cellular assays and animal models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1341224-83-6
• MW: 568.59
• Purity: 99.14%
• Formula: C₂₉H₃₁F₃N₆O₃
• SMILES: [H][C@@]1(CC[C@](O)(CC1)c1ccc(cn1)-c1ncccn1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F
• Target: CCR
• Solubility: DMSO:100 mg/mL (175.87 mM);Ethanol:100 mg/mL (175.87 mM);10% EtOH+40% PEG300+5% Tween-80+45% Saline:10 mg/mL (17.59 mM)

Bioactivity

• Target IC50:
  CCR2 (mouse):17 nM|CCR2 (human):5.2 nM|CCR2 (rat):13 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, INCB 8761, INCB8761, INCB-8761, CC chemokine receptor, CCR2, CCR, PF 4136309, PF4136309, PF-4136309

Compound Identifiers

PubChem CID

11192346