PERFORIN antibody

• Catalog Number: orb67011
• Category: Antibodies
• Description: Rabbit polyclonal to PERFORIN.PERFORIN (PRF1) is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upondegranulation, PERFORIN inserts itself into the target cell's plasma membrane, forming a pore. Thelytic membrane-inserting part of PERFORIN is the MACPF domain, which shares homology withcholesterol-dependent cytolysins from Gram-positive bacteria. PERFORIN has structural andfunctional similarities to complement component 9 (C9). Like C9, PERFORIN creates transmembranetubules and is capable of lysing non-specifically a variety of target cells. PERFORIN is one of themain cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cellandnatural killer-cell-mediated cytolysis. Defects in PERFORIN cause familial hemophagocyticlymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: middle region of mouse PERFORIN
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 62
• UniProt ID: P31240
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-PERFORIN antibody,anti-Cytolysin antibody,ant
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Jurkat(Lane1) and mouse liver(Lane2) using PERFORIN antibody