Pentostatin

SKU: orb1224751

Description

Pentostatin is an extremely potent (Ki = 2.5 pM), irreversible inhibitor of adenosine deaminase. This compound is effective against a variety of cancer cell lines.(In Vitro):In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.

Key Properties

• CAS Number: 53910-25-1
• MW: 268.27
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₆N₄O₄
• SMILES: O[C@H]1C2=C(N([C@H]3O[C@H](CO)[C@@H](O)C3)C=N2)N=CNC1
• Target: AChR
• Solubility: Water: 100 mM; DMSO: 75 mM

Bioactivity

• In Vivo:
  In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i. v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20, 000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CI 825 | CL 67310465 | DCF | Deoxycoformycin | NSC 218321 | NSC 247520

Quick Database Links

Gene Symbol

AChR