Pentagastrin

SKU: orb1222049

Description

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system.(In Vitro):Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.(In Vivo):Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5534-95-2
• MW: 767.89
• Purity: >98% (HPLC)
• Formula: C₃₇H₄₉N₇O₉S
• SMILES: CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
• Target: Others
• Solubility: DMSO : ≥ 34 mg/mL; 44.28 mM

Bioactivity

• In Vivo:
  Pentagastrin (ICI-50123) (80 μg/kg/h; i. v. ; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury. Animal model: Male Sprague-Dawley rats (approximately 200 g). Dosage: 80 μg/kg/h. Administration: Intravenous injection. Result: Protected rat gastric mucosa from acidified aspirin injury. Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
• In Vitro:
  Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold. Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pentagastrin | NCGC00183362-01 | Pentagastrinum | Peptavlon

Quick Database Links

Gene Symbol

Others