PEG300

SKU: orb2279180

Description

PEG300 is a neutral, water-soluble, and biocompatible polyethylene glycol polymer with an average molecular weight of 300. It is widely used in research as a solvent, cryoprotectant, and formulation agent for in vitro assays and in vivo drug delivery studies due to its low immunogenicity.

Key Properties

• CAS Number: 25322-68-3
• MW: 722.863
• Purity: mw~300
• Formula: C₃₂H₆₆O₁₇
• SMILES: OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
• Target: Others
• Solubility: H2O:50 mg/mL;DMSO:100 mg/mL

Bioactivity

• In Vivo:
  METHODS: To study the effect of Dasatinib on diabetic cardiomyopathy, Dasatinib (5 mg/kg in 10% DMSO + 90% PEG-300) was administered by gavage to BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice once a week for four weeks. RESULTS: Dasatinib counteracted obesity in the heart and bone marrow as well as cardiac fibrosis. METHODS: To test the in vivo effects of treatment with ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab, cetuximab (25 mg/kg in 10% 1-methyl-2-pyrrolidinone + 90% PEG 300 twice weekly) and ALW-II-41-27 (30 mg/kg/day) were injected intraperitoneally into balb/c athymic (nu+/nu+) mice bearing human colorectal adenocarcinoma tumor HCT15 for six weeks. RESULTS: The combination of ALW-II-41-27 and cetuximab significantly inhibited tumor growth.
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• In Vitro:
  METHODS: Human colorectal adenocarcinoma cells Caco-2 were treated with PEG300 (30 w/v% in 100 μL) for 30 min, and cell growth inhibition was detected by MTT. RESULTS: PEG300 treatment severely reduced cell viability, and the cell survival rate was only 20%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

biocompatible, PEG300, PEG-300, PEG 300, polymer, Polyethylene glycol300, Polyethylene glycol-300, Polyethylene glycol 300, inhibit, immunogenic, marker, Inhibitor, gastrointestinal

Compound Identifiers

PubChem CID

134694962