PDCD1 Antibody / PD-1 / PD1

SKU: orb386225

Description

PDCD1 (Programmed cell death-1 protein), also called PD1 and CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD1 is expressed by few B-cells, so may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma.

Images & Validation

• Tested Applications: IHC-P
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human
• Application Notes:
  Titering of the recombinant PD1 antibody may be required for optimal performance.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Recombinant
• Isotype: Rabbit IgG, kappa
• Clone No.: PDCD1/1410R
• Immunogen: A partial length human protein was used as the immunogen for the recombinant PD1 antibody.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Disclaimer: For research use only

IHC testing of FFPE human tonsil with recombinant PD1 antibody (clone PDCD1/1410R). Required HIER: steam sections in 10 mM Tris with 1 mM EDTA, pH9, for 10-20 min.

SDS-PAGE analysis of purified, BSA-free recombinant PD1 antibody (clone PDCD1/1410R) as confirmation of integrity and purity.

Quick Database Links

UniProt

Q15116