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Catalog Number | orb1921778 |
---|---|
Category | Antibodies |
Description | Procalcitonin (PCT) is the 116 amino acid precursor of the hormone calcitonin, produced by the C cells of the thyroid. In health, this is the only tissue able to transcribe and translate the PCT gene (CALC-1). The transcript is quickly cleaved into three products: katacalcin, calcitonin and an N terminal fragment.Only a small amount of PCT is released into the general circulation such that in health concentrations are <0.05 ng/L. In the presence of bacterial infection, however, PCT production is activated in all parenchymal tissues and concentrations rapidly increase (these tissues lack the ability to cleave PCT).Mediators of viral infection (interferon-gamma) attenuate PCT levels, making it a more specific marker of bacterial infection. PCT is detectable within 2-4 hours of infection, peaks at 6 hours and maintained a plateau through 8 and 24 hours before they began to drop. It is degraded by proteolysis with renal excretion playing only a minor route. |
Species/Host | Mouse |
Clonality | Monoclonal |
Tested applications | CLIA, LF |
Form/Appearance | Purified,Liquid |
Purity | > 95% pure (SDS-PAGE). |
Conjugation | Unconjugated |
MW | 150 kDa |
Storage | For long term storage, the product should be stored at -20°C or lower. |
Note | For research use only |
Sample Types | Test sample type: Serum / Plasma. Test sample source: Human |
Expiration Date | 12 months from date of receipt. |
CLIA, LF | |
Mouse | |
Monoclonal | |
Unconjugated |
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