PCT Antigen

• Catalog Number: orb1921780
• Category: Proteins
• Description: Procalcitonin (PCT) is the 116 amino acid precursor of the hormone calcitonin, produced by the C cells of the thyroid. In health, this is the only tissue able to transcribe and translate the PCT gene (CALC-1). The transcript is quickly cleaved into three products: katacalcin, calcitonin and an N terminal fragment.Only a small amount of PCT is released into the general circulation such that in health concentrations are ＜0.05 ng/L. In the presence of bacterial infection, however, PCT production is activated in all parenchymal tissues and concentrations rapidly increase (these tissues lack the ability to cleave PCT).Mediators of viral infection (interferon-gamma) attenuate PCT levels, making it a more specific marker of bacterial infection. PCT is detectable within 2-4 hours of infection, peaks at 6 hours and maintained a plateau through 8 and 24 hours before they began to drop. It is degraded by proteolysis with renal excretion playing only a minor route.
• Tested applications: CLIA, LF, Turbidimetry
• Form/Appearance: Purified,Liquid
• Purity: > 90% pure (SDS-PAGE).
• MW: 13.61kDa
• Source: HEK293
• Storage: For long term storage, the product should be stored at -20°C or lower.
• Note: For research use only
• Sample Types: Test sample type: Serum / Plasma. Test sample source: Human
• Expiration Date: 6 months from date of receipt.