PATULIN

SKU: orb1221540

Description

Patulin is a mycotoxin produced by a variety of molds commonly found in rotting apples including Aspergillus and Penicillium.

Key Properties

• CAS Number: 149-29-1
• MW: 154.12
• Purity: >98% (HPLC)
• Formula: C₇H₆O₄
• SMILES: C1C=C2C(=CC(=O)O2)C(O1)O
• Target: Others
• Solubility: Ethanol:<1 mg/mL;DMSO:<1 mg/mL;Water:100 mg/mL (127.77 mM)

Bioactivity

• In Vivo:
  Animal model: Male CF-1 mice. Dosage: 1-3.75 mg/kg. Administration: i.p. , once time. Result: Increased the damage index and TBARS production in the brain, liver and kidneys of mice in a dose-dependently manner (2.5-3.75 mg/kg). Reduced the concentration of the reduced form of intracellular glutathione in the brain, liver and kidneys of mice at a dose of 2.5-3.75 mg/kg. Decreased the levels of GSH. Increased lipid peroxidation.
• In Vitro:
  Apoptosis Analysis Cell line: HepG2 cells. Concentration: 2 μM. Incubation time: 6-24 h. Result: Increased the levels of active cleaved caspase-3 at 12 or 24 h. Western blot analysis. Cell line: HepG2 cells. Concentration: 2 μM. Incubation time: 3-24 h. Result: Increases the LC3-II levels. Immunofluorescence Cell line: HepG2 cells. Concentration: 2 μM. Incubation time: 6-24 h. Result: Increased the numbers of swollen mitochondria with scarce or disordered cristae.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clavacin | Expansin | Claviform

Quick Database Links

Gene Symbol

Others