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PARP1/BRD4-IN-3

SKU: orb2664990

Description

PARP1/BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0/G1 phase. Additionally, PARP1/BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.

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Key Properties

TargetDNA/RNA Synthesis,Epigenetic Reader Domain,PARP,Apoptosis

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

PARP1/BRD4-IN-3 (orb2664990)

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