Parecoxib

SKU: orb1225771

Description

A potent and selective COX-2 inhibitor; a water-soluble prodrug of valdecoxib.Pain Approved(In Vitro):Parecoxib (0-200 μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells.Parecoxib (200 μM; 24-48 hours) results in a decreasee migratory ability of U343 cells than PBS-treated group.(In Vivo):Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 198470-84-7
• MW: 370.4222
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₂O₄S
• SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C1=C(C)ON=C1C1=CC=CC=C1
• Target: COX
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms. Animal model: Naive adult male ICR mice, 15 weeks old and weighing 25-35 g. Dosage: 2.5, 5.0 or 10 mg/kg. Administration: Intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days. Result: Exerted an anxiolytic-like effect in the elevated plus-maze test.
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• In Vitro:
  Cell Viability Assay Cell line: GBM cells: U251 and U343 cells. Concentration: 0 μM, 20 μM, 50 μM, 100 μM and 200 μM. Incubation time: 24-48 hours. Result: Resulted in a slower BrdU incorporation rate of GBM cells including U251 and U343 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SC-69124

Quick Database Links

Gene Symbol

COX