Paprotrain

SKU: orb1309282

Description

Paprotrain is a potent and selective inhibitor of the mitotic kinesin MKLP-2, exhibiting an IC50 of 1.35 µM and a Ki of 3.36 µM against its ATPase activity. This small molecule is a valuable chemical probe for studying cytokinesis and cell division in both in vitro biochemical and cellular assays.

Research Area

Signal Transduction

Key Properties

• CAS Number: 57046-73-8
• MW: 245.28
• Purity: 99.91%
• Formula: C₁₆H₁₁N₃
• SMILES: N#C\C(=C/c1cccnc1)c1c[nH]c2ccccc12
• Target: Kinesin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.31 mM);DMSO:125 mg/mL (509.62 mM)

Bioactivity

• Target IC50:
  MKLP2:1.35 μM|MKLP2:3.36 Μm(Ki)
• In Vitro:
  Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Paprotrain, MKLP-2, inhibit, Kinesin, (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Compound Identifiers

PubChem CID

12248889