PAPA NONOate

SKU: orb1983247

Description

PAPA NONOate is a pH-sensitive nitric oxide donor used in cancer research for its potential antitumor effects and in studies of diabetic wound healing. Its applications include in vitro cytotoxicity assays and in vivo models investigating NO's role in angiogenesis and tissue repair.

Research Area

Cell Biology

Key Properties

• CAS Number: 146672-58-4
• MW: 176.22
• Purity: >98%
• Formula: C₆H₁₆N₄O₂
• SMILES: O=NN(O)N(CCC)CCCN
• Target: Ion channel
• Solubility: Soluble in Water or Ethanol.

Bioactivity

• In Vivo:
  In phosphate-buffered saline, treatment of rat dorsal skin wounds with 100 μM PAPA NONOate resulted in improved wound healing rates in the treated group.
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• In Vitro:
  Incubation with PAPA NONOate (50 μM) for 12 hours significantly reduced the increase in caspase-3-like activity induced by caspase-3 overexpression by 70%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, NO Synthase, NOSynthase, Endogenous Metabolite

Compound Identifiers

PubChem CID

135503453