pan-KRAS-IN-2

SKU: orb2277671

Description

Pan-KRAS-IN-2 is a potent, broad-spectrum KRAS inhibitor effective at nanomolar concentrations against wild-type KRAS and multiple G12 and Q61H mutants. It exhibits markedly weaker activity against the G13D mutant. This compound is a valuable chemical probe for investigating KRAS-driven cancers in both cellular and animal model studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2882825-14-9
• MW: 584.66
• Formula: C₃₄H₃₄F₂N₄O₃
• SMILES: C(OC=1N=C(C2=C(N1)C(C)=C(C=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CCCOCC5)[C@@]67N(C[C@H](F)C6)CCC7
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166162638