Paeonol

SKU: orb1304871

Description

Paeonol, a bioactive compound derived from Paeonia suffruticosa, acts as a monoamine oxidase (MAO) inhibitor, showing activity against both MAO-A and MAO-B isoforms. This small molecule is utilized in neuroscience research, particularly in studies investigating neuroinflammation and depression using in vitro enzymatic assays and in vivo animal models.

Research Area

Cell Biology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 552-41-0
• MW: 166.17
• Purity: >99.99% (May vary between batches)
• Formula: C₉H₁₀O₃
• SMILES: COC1=CC(O)=C(C=C1)C(C)=O
• Target: MAO,Autophagy,Monoamine Oxidase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:252 mg/mL (1516.52 mM);Ethanol:33 mg/mL (198.59 mM)

Bioactivity

• Target IC50:
  MAO-A:54.6 μM|MAO-B:42.5 μM
• In Vivo:
  Danpi phenol mitigates allergic reactions by modulating histamine and TNF-α (tumor necrosis factor-alpha) levels.
• In Vitro:
  Paeonol exhibits toxicity in mice with an LD50 range of 608-899 mg/kg when administered intraperitoneally (i.p.).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAO-B, MAO, MAO-A, Inhibitor, inhibit, MonoamineOxidase, Monoamine Oxidase, Paeonol, Autophagy, Peonol

Compound Identifiers

PubChem CID

11092