P32/98 hemifumarate

SKU: orb1704908

Description

P32/98 hemifumarate is a potent and selective DPP4 inhibitor used in diabetes research. It demonstrates anti-hyperglycemic effects by enhancing insulin sensitivity and β-cell function in vivo, as shown in Zucker diabetic fatty (ZDF) rat studies. Its application extends to investigating inflammatory conditions like colitis.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 251572-86-8
• MW: 520.71
• Purity: 99.07% (May vary between batches)
• Formula: C₂₂H₄₀N₄O₆S₂
• SMILES: OC(/C=C/C(O)=O)=O.CC[C@H](C)[C@H](N)C(N1CCSC1)=O.CC[C@H](C)[C@H](N)C(N2CCSC2)=O
• Target: DPP-4

Bioactivity

• Target IC50:
  DPP4:130 nM (Ki)
• In Vivo:
  In Zucker diabetic fatty rats, P32/98 (hemifumarate) (25 mg/kg; oral gavage; once daily) significantly improved glucose tolerance.
• In Vitro:
  In porcine proximal tubular cells,P32/98 (hemifumarate) (10 μM; 96 hours) showed no cytotoxicity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DPP4, DPP-4, P32/98 (hemifumarate), P32/98 (hemifumarate)(136259-20-6 free base), P32/98

Compound Identifiers

PubChem CID

131668501