Oxaceprol

SKU: orb1302156

Description

Oxaceprol (N-Acetyl-L-hydroxyproline) is a small molecule therapeutic used in osteoarthritis research. It has been investigated in both in vitro and in vivo models for its potential effects on cartilage metabolism and inflammatory pathways.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 33996-33-7
• MW: 173.17
• Purity: 99.32% (May vary between batches)
• Formula: C₇H₁₁NO₄
• SMILES: CC(=O)N1CC(O)CC1C(O)=O
• Target: Amino Acids and Derivatives,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (23.1 mM);DMSO:100 mg/mL (577.47 mM)

Bioactivity

• In Vivo:
  Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p.o.). In the same dose range, oxaceprol was comparable to indomethacin (3 mg/kg p.o.) as an inhibitor of yeast hyperalgaesia and at 6-50 mg/kg/day p.o. had a mild, variable inhibitory effect on cotton pellet granuloma formation

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Oxaceprol, osteoarthritis, N-Acetyl-L-hydroxyproline, inhibit, Inhibitor, antirheumatic, anti-inflammatory, arthritis, rheumatoid

Compound Identifiers

PubChem CID

538341