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OSU-03012

SKU: orb1224096

Description

OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM; decreases incidences of carcinoma and metastasis in transgenic mouse model of prostate cancer.Blood Cancer Phase 1 Clinical.

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Key Properties

CAS Number742112-33-0
MW460.45
Purity>98% (HPLC)
FormulaC26H19F3N4O
SMILESNCC(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1=CC2=C(C=C1)C1=CC=CC=C1C=C2)C(F)(F)F
TargetPDK
SolubilityDMSO: 9 mg/mL (19.5 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AR-12 | AR 12 | OSU 03012

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    C26H19F3N4O

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO), 500 mg
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Protocol Information

OSU-03012 (orb1224096)

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Available Sizes

Select a size below

500 mg
2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 220.00
50 mg
$ 390.00
100 mg
$ 500.00
200 mg
$ 640.00