Optovin

SKU: orb1300612

Description

Optovin

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 348575-88-2
• MW: 315.41
• Purity: 100.00%
• Formula: C₁₅H₁₃N₃OS₂
• SMILES: Cc1cc(\C=C2/SC(=S)NC2=O)c(C)n1-c1cccnc1
• Target: TRP/TRPV Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.34 mM);DMSO:59 mg/mL (187.06 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  TRPA1:2 μM(EC50)
• In Vivo:
  Optovin enables real-time optical control of neurons, and also elicits nociceptive behaviors in adult mice. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination.
• In Vitro:
  Optovin activates human TRPA1 via structure dependent photochemical reactions.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

light-mediated, inhibit, neuronal, Optovin, Inhibitor, excitation, photoactivated, TRPChannel, TRPA1, TRPV Channel, TRP Channel, TRPVChannel, Transient receptor potential channels

Compound Identifiers

PubChem CID

1365103