Optovin

SKU: orb1222336

Description

Optovin is a photoactive TRPA1 activator. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans.

Key Properties

• CAS Number: 348575-88-2
• MW: 315.41
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₃OS₂
• SMILES: S1C(=S)NC(=O)/C/1=C\c1c(n(c(c1)C)c1cnccc1)C
• Target: Sodium Channel
• Solubility: DMSO : ≥ 37 mg/mL; 117.31 mM

Bioactivity

• In Vivo:
  Optovin (1-10 μM) causes light-dependent motor excitation In vivo. Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice. Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish.
• In Vitro:
  Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM. Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons. Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Optovin

Quick Database Links

Gene Symbol

Sodium Channel