Ondansetron hydrochloride

SKU: orb1227091

Description

Ondansetron is a serotonin 5-HT receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.(In Vivo):Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg), in radiation-induced pica model.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 103639-04-9
• MW: 365.86
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₉N₃O·HCl·2H₂O
• SMILES: O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl
• Target: 5-HT Receptor
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99, 994 (15 mg/kg), in radiation-induced pica model. Animal model: Male mice of ICR strain (8-week-old; 30-36 g; radiation-induced pica model (kaolin ingestion behavior “pica” may be analogous to nausea and vomiting in mice)). Dosage: 2 mg/kg. Administration: Intraperitoneal injection; single. Result: Slightly reduced the radiation-induced kaolin consumption by dexamethasone to 48% of the control. Showed good activity of blocking radiation sickness by combining with Dexamethasone (2 mg/kg) and CP-99, 994 (15 mg/kg).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ondansetron hydrochloride

Quick Database Links

Gene Symbol

5-HT Receptor