NTN21277(Gefitinib-based PROTAC 3)

• Catalog Number: orb757609
• Category: Small Molecules
• Description: Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
• CAS Number: [2230821-27-7]
• MW: 934.522
• SMILES: N(C(=O)[C@H](NC(=O)CCOCCOCCCCCOC1C(OC)=CC2C(C=1)=C(NC1=CC=C(F)C(Cl)=C1)N=CN=2)C(C)(C)C)1C[C@@H](O)C[C@@H]1C(NCC1=CC=C(C2SC=NC=2C)C=C1)=O
• Formula: C₄₇H₅₇ClFN₇O₈S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.