NS6180

SKU: orb1307536

Description

NS6180 is a highly selective, nanomolar-potency inhibitor of the KCa3.1 channel (IC50 = 9 nM). This compound suppresses T-cell activation and inflammatory responses, making it a valuable research tool for studying autoimmune diseases, fibrosis, and atherosclerosis in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 353262-04-1
• MW: 323.33
• Purity: ≥95%
• Formula: C₁₆H₁₂F₃NOS
• SMILES: FC(F)(F)c1cccc(CN2C(=O)CSc3ccccc23)c1
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.19 mM);DMSO:55 mg/mL (170.1 mM)

Bioactivity

• Target IC50:
  KCa3.1 channel:9 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inflammatory bowel disease (IBD), NS 6180, NS6180, NS-6180, inhibit, KCa3.1 channel, KcsA, Inhibitor, PotassiumChannel, Potassium Channel, pharmacokinetics, rats

Compound Identifiers

PubChem CID

11837221