Norovirus GII.4 P domain Antibody

• Catalog Number: orb1821611
• Category: Antibodies
• Description: Norovirus GII.4 P domain Antibody
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: A1431
• Tested applications: Blocking, ELISA, NeA
• Reactivity: Virus
• Isotype: IgG1
• Immunogen: The original antibody was isolated from an anti-NoV GII.4c IgG serum antibody repertoire generated from three donors that experienced a significant increase in GII.4 titer after immunization with the bivalent GII.4c + GI.1 VLP vaccine.
• Concentration: 1 mg/ml
• Conjugation: Unconjugated
• Target: Norovirus GII.4 P domain
• UniProt ID: S5YAA0
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: VP1; NoV; HuNoV; NoV VP1; capsid protein VP1; majo
• Note: For research use only
• Application notes: This antibody showed broad blockade towards to all known historical GII.4 strains from 1987 onwards and neutralized the pandemic GII.P16-GII.4 Sydney strain. This antibody is also capable of blocking the VLP binding to histoblood group antigens (HBGAs). Structure revealed conserved epitopes, which were occluded on the virion or partially exposed, allowing for broad blockade with neutralizing activity. The HBGA blocking assay was used to characterize A1431 against a panel of pandemic norovirus GII.4 strains. ELISA was used to determine the binding specificity of the antibody for GII.4c VLP (PMID: 31216462).
• Expiration Date: 12 months from date of receipt.