NO 711

SKU: orb1739066

Description

NO 711 (NNC-711 free acid) is a potent and selective GAT-1 inhibitor that elevates synaptic GABA levels. This action enhances non-REM sleep in vivo and has demonstrated efficacy in preventing and treating paclitaxel-induced neuropathic pain in preclinical models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 159094-94-7
• MW: 350.41
• Purity: 99.70% (May vary between batches)
• Formula: C₂₁H₂₂N₂O₃
• SMILES: OC(=O)C1=CCCN(CCON=C(c2ccccc2)c2ccccc2)C1
• Target: GABA Receptor

Bioactivity

• In Vivo:
  Methods: 12-, 18-, and 25-day-old rat pups with implanted electrodes were used. Epileptic foci were induced by local application of dithiothreitol methyl iodide (BMI) via an implanted cannula over the sensorimotor cortical area, and cortical afterepileptic discharges (ADs) were induced by low-frequency stimulation (8 Hz) of the same cortical area. Epileptic foci were formed after pretreatment with NO 711 (1 or 10 mg/kg, i.p.), and epileptic ADs were induced in a second experimental series. NNC-711 was then applied at the same dose, and stimulation was repeated. Results: NO 711 did not block the formation of epileptogenic foci, but it significantly inhibited the spontaneous transition of interictal focal to ictal activity in all age groups. In 18- and 25-day-old rats, the intensity of movements accompanying sensorimotor cortical stimulation was smaller under the influence of NNC-711.
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• In Vitro:
  Treatment of microglia with NO 711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NNC-711 free acid, NO711

Compound Identifiers

PubChem CID

4515