NNC 05-711

SKU: orb1704292

Description

NNC 05-711 hydrochloride is a selective GAT-1 inhibitor that blocks GABA reuptake, elevating synaptic GABA levels. This mechanism supports its use in research on epilepsy and pain, with studies demonstrating anticonvulsant effects in animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145645-62-1
• MW: 386.87
• Purity: 99.92% (May vary between batches)
• Formula: C₂₁H₂₃ClN₂O₃
• SMILES: Cl.OC(=O)C1=CCCN(CCON=C(c2ccccc2)c2ccccc2)C1
• Target: GABA Receptor
• Solubility: H2O:2 mg/mL (5.17 mM);DMSO:80 mg/mL (206.79 mM)

Bioactivity

• In Vivo:
  Methods: NNC 05-711 (50, 100, 200 μg/10 μL, intrathecal injection, once a day) was used to treat rats with chronic sciatic nerve constriction injury (CCI) and its analgesic effect was observed. Results: NNC 05-711 exerted an effective analgesic effect in the CCI rat model. Compared with the CCI + saline group, the paw withdrawal threshold (WT) and paw withdrawal latency (WL) values ​​increased after 1 day.
• In Vitro:
  Treatment of microglia with NNC 05-711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake in microglia.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NNC 05711, NNC 711, NNC05-711, NNC711, NNC-711, NO-711 hydrochloride, NO-711-hydrochloride

Compound Identifiers

PubChem CID

123738