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Catalog Number | orb1290228 |
---|---|
Category | Antibodies |
Description | Nivolumab biosimilar antibody |
Species/Host | Mouse |
Clonality | Monoclonal |
Tested applications | ELISA, FC |
Reactivity | Human |
CAS Number | 946414-94-4 |
Isotype | IgG4-kappa |
Purity | > 95% |
Conjugation | Unconjugated |
Target | PDCD1/PD1/CD279 |
Source | CHO cells |
Biological Activity | Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus. |
Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks). Store at -20 °C 12 months. Store at -80°C long term. |
Buffer/Preservatives | PBS buffer pH 7.5 |
Alternative names | BMS-936558, MDX-1106, ONO-4538 Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Recombinant | |
Unconjugated |
ELISA, FC, Functional Studies, ICC, IF, IP, NeA | |
Unconjugated |
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