Nitazoxanide

SKU: orb1308235

Description

Nitazoxanide (NSC-697855) is a synthetic benzamide compound with broad-spectrum antiprotozoal activity, primarily through inhibition of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme. It is widely used in research for studying cryptosporidiosis and giardiasis in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55981-09-4
• MW: 307.28
• Purity: >98%
• Formula: C₁₂H₉N₃O₅S
• SMILES: C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(OC(C)=O)C=CC=C2
• Target: Antibiotic
• Solubility: Soluble in DMSO (up to at least 50 mg/ml)

Bioactivity

• Target IC50:
  Influenza virus ranges (canine):0.17-0.21 μM
• In Vivo:
  Nitazoxanide effectively inhibits the growth of a broad spectrum of protozoans and helminths, such as Blastocystis hominis, Entamoeba histolytica, and Trichomonas vaginalis, without exhibiting cytotoxicity. It demonstrates inhibitory concentrations against E. histolytica (IC50=0.017 mg/mL, IC90=0.776 mg/mL), G. intestinalis (IC50=0.004 mg/mL, IC90=0.067 mg/mL), and T. vaginalis (IC50= 0.034 mg/mL, IC90=2.046 mg/mL).
• In Vitro:
  In a model of abiotic piglet diarrhea, oral administration of Nitazoxanide (250 mg/kg/day) was effective in reducing the survival of parasites within the host organism.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, bacteria infecting, anthelmintic, helminths, Inhibitor, gastroenteritis ,virus, Giardia lamblia, enteric, NSC697855, NSC-697855, Nitazoxanide, NTZ, parasitic, Parasite, NSC 697855, inhibit, JEV, Influenza Virus, InfluenzaVirus, PFOR, protozoa, trophozoite

Compound Identifiers

PubChem CID

41684