NH-3

• Catalog Number: orb1303228
• Category: Small Molecules
• Description: NH-3
• CAS Number: 447415-26-1
• Purity: 98%
• MW: 473.52
• SMILES: CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O
• Formula: C₂₈H₂₇NO₆
• Biological Activity: NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.