Neobavaisoflavone

SKU: orb1222277

Description

Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells.

Key Properties

• CAS Number: 41060-15-5
• MW: 322.36
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈O₄
• SMILES: CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C
• Target: DNA polymerase
• Solubility: DMSO : ≥ 31 mg/mL; 96.17 mM

Bioactivity

• In Vivo:
  Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice. Animal model: C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries. Dosage: 30 mg/kg. Administration: i.p. for 6 weeks. Result: Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice.
• In Vitro:
  Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED50=25 μM) and cytokine (ED50s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages. Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED50 of 19.94 μM in activated RAW264.7 cells. Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells. Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner. Neobavaisoflavone (2-8 μM; 7 d) inhibitsRANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neobavaisoflavone

Quick Database Links

Gene Symbol

DNA polymerase