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NEO Protein, K. pneumoniae, Recombinant
Catalog Number: orb1961574
| Catalog Number | orb1961574 |
|---|---|
| Category | Proteins |
| Description | Aminoglycoside 3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3') is primarily found in certain species of gram-positive bacteria. |
| Tag | Tag Free |
| Purity | 98.00% |
| MW | 26-30 KDa (reducing condition) |
| UniProt ID | P00552 |
| Protein Sequence | Met1-Phe264 |
| Expression System | E. coli |
| Biological Origin | Klebsiella pneumoniae |
| Biological Activity | Aminoglycoside 3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3') is primarily found in certain species of gram-positive bacteria. |
| Expression Region | Met1-Phe264 |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 6 months from date of receipt. |
