NEDD4 antibody

• Catalog Number: orb67227
• Category: Antibodies
• Description: Rabbit polyclonal to NEDD4.Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form ofa thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4 is also involved inthe pathway leading to the degradation of VEGFR-2/KDFR independent of its ubiquitin-ligase activity.NEDD4 can monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization anddegradation in lysosomes. In addition, NEDD4 is part of a signaling complex composed of NEDD4,RAP2A and TNIK, which regulates neuronal dendrite extension and arborization during development.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: middle region of human NEDD4
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 149
• UniProt ID: P46934
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-NEDD4 antibody,anti-E3 ubiquitinprotein ligas
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela(Lane1) and mouse brain(Lane2) using NEDD4 antibody