NBQX disodium

SKU: orb1701884

Description

NBQX Disodium

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 479347-86-9
• MW: 380.2415
• Purity: 98.22%
• Formula: C₁₂H₆N₄Na₂O₆S
• SMILES: O=C1[N-]C2=C([N-]C1=O)C3=CC=CC(S(=O)(N)=O)=C3C([N+]([O-])=O)=C2.[Na+].[Na+]
• Target: iGluR,GluR
• Solubility: H2O:34.2 mg/mL (89.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

• Target IC50:
  Kainic acid:0.7 ± 0.03 μM|AMPA:0.7 ± 0.1 μM
• In Vivo:
  Administration of NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) exhibits a reduction in PTZ-induced seizures. In a rat model of focal ischemia, NBQX disodium demonstrates neur Protective effects when administered intravenously as a bolus dose of 30 mg/kg a the time of MCA occlusion, followed by an additional dose at 1 hour post-occlusion.
• In Vitro:
  In HIP-009 cells, NBQX disodium salt inhibited both AMPA or kainic acid (KA) induced signals in a concentration dependent manner, with IC50 Values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively the AMPA-evoked calcium rise was completely inhibited by NBQX disodium salt, whereas 68.6% ± 1.3% Inhibition o the KA-induced signal was observed with 30 μM of NBQX disodium salt treatment

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPA, NBQX, NBQX 2Na, NBQX Disodium, FG 9202, FG9202, FG9202 disodium, FG-9202

Compound Identifiers

PubChem CID

6098006