Nav1.8 antibody

• Catalog Number: orb148843
• Category: Antibodies
• Description: Mouse monoclonal to Nav1 (HRP). 8. Nav1. 8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1. 8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1. 8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals..
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: S134
• Tested applications: AM, ICC, IHC, WB
• Reactivity: Human, Monkey, Mouse, Rat
• Isotype: IgG2a
• Immunogen: Fusion protein amino acids 1724-1956 of rat Nav1.8
• Concentration: 1 mg/ml
• Dilution range: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
• Conjugation: HRP
• MW: 220kDa
• Target: Nav1.8
• Entrez: 29571
• UniProt ID: Q62968
• NCBI: NP_058943.1
• Storage: Conjugated antibodies should be stored at 4°C
• Buffer/Preservatives: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Alternative names: mPN3 antibody, Peripheral nerve sodium channel 3 a
• Note: For research use only
• Application notes: 1 µg/ml of SMC-342 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Expiration Date: 12 months from date of receipt.