Natalizumab biosimilar antibody

• Catalog Number: orb1290234
• Category: Antibodies
• Description: Natalizumab biosimilar antibody
• Species/Host: Mouse
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human
• CAS Number: 189261-10-7
• Isotype: IgG4-kappa
• Purity: > 95%
• Conjugation: Unconjugated
• Target: ITGA4/CD49d
• Source: CHO cells
• Biological Activity: Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks). Store at -20 °C 12 months. Store at -80°C long term.
• Buffer/Preservatives: PBS buffer pH 7.5
• Alternative names: AN 100226, BG00002
• Note: For research use only
• Expiration Date: 12 months from date of receipt.