Naringin

SKU: orb1310459

Description

Naringin, a bioactive flavanone glycoside, is widely used in research for its lipid-lowering, antioxidant, and anticancer properties. It serves as a key compound in metabolic, oncology, and pharmacology studies, with applications in both in vitro enzyme inhibition assays and in vivo models of hyperlipidemia and chemoprevention.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 10236-47-2
• MW: 580.53
• Purity: 99.23% (May vary between batches)
• Formula: C₂₇H₃₂O₁₄
• SMILES: O=C1C=2C(O[C@@H](C1)C3=CC=C(O)C=C3)=CC(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC2O
• Target: Cytochromes P450,Autophagy,Endogenous Metabolite,Mitophagy
• Solubility: DMSO:250 mg/mL (430.64 mM);Ethanol:1 mg/mL (1.72 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  The Lethal Dose 50 for mice:1650 mg/kg.
• Cell Research:
  HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP450, CYPs, Cytochrome P450, Autophagy, Mitochondrial Autophagy, Naringin, Naringoside, Mitophagy, inhibit, Inhibitor, Endogenous Metabolite, EndogenousMetabolite

Compound Identifiers

PubChem CID

442428