Nabumetone

SKU: orb1309207

Description

Nabumetone

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 42924-53-8
• MW: 228.29
• Purity: 98.91%
• Formula: C₁₅H₁₆O₂
• SMILES: C(CC(C)=O)C1=CC2=C(C=C(OC)C=C2)C=C1
• Target: COX,Glutathione Peroxidase
• Solubility: Ethanol:24 mg/mL (105.13 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.76 mM);DMSO:55 mg/mL (240.92 mM)

Bioactivity

• In Vivo:
  Nabumetone undergoes extensive first-pass metabolism to form its main active metabolite (6-MNA) in the systemic circulation, which is capable of inhibiting COX-2.
• In Vitro:
  Nabumetone exhibits anti-inflammatory activity in rat models of carrageenan-induced edema and UV-induced erythema in guinea pigs. In a rat granuloma model, Nabumetone is non-toxic at concentrations higher than the minimum effective dose. Furthermore, in adjuvant-induced arthritic rats, Nabumetone demonstrates good gastric tolerability at doses exceeding those required for anti-inflammatory efficacy.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nabumetone, inhibit, MPO, Inhibitor, GlutathionePeroxidase, Glutathione Peroxidase, COX, BRL 14777, BRL14777, BRL-14777, Cyclooxygenase, COX-1, COX-2

Compound Identifiers

PubChem CID

4409