N-Acetyl-5-hydroxytryptamine

SKU: orb1226788

Description

N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase.

Key Properties

• CAS Number: 1210-83-9
• MW: 218.25
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₄N₂O₂
• SMILES: CC(=O)NCCC1=CNC2=C1C=C(O)C=C2
• Target: 5-HT Receptor
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation In vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF-and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect. These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.
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• In Vitro:
  N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-Acetyl-5-hydroxytryptamine | NAS

Quick Database Links

Gene Symbol

5-HT Receptor