Myricitrin

SKU: orb1305064

Description

Myricitrin is a flavonoid isolated from Myrica cerifera root bark, known for its antinociceptive properties. Research applications include investigating its mechanisms in pain and inflammation models, both in vitro and in animal studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 17912-87-7
• MW: 464.38
• Purity: 99.72% (May vary between batches)
• Formula: C₂₁H₂₀O₁₂
• SMILES: C[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2cc(O)c(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
• Target: NO Synthase,TNF,PKC,Parasite
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (7.11 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:1 mg/mL (2.15 mM);DMSO:86 mg/mL (185.19 mM)

Bioactivity

• In Vivo:
  In rodent models of chemical and mechanical pain, Flurbiprofen activates protein kinase Cα and PKCε, while Myricitrin blocks this action, thereby exerting a significant analgesic effect. The pain-relief mechanism of Myricitrin is attributed to a decrease in calcium ion influx and the opening of voltage-dependent and small-conductance calcium-activated potassium (K+) channels. Additionally, Myricitrin inhibits the expression of the p53 gene, which leads to the activation of caspase-3 and the MAPK signaling pathway, while altering the expression pattern of anti-apoptotic and pro-apoptotic genes. Consequently, this reduces H₂O₂-induced apoptosis in vascular endothelial cells.
• In Vitro:
  In mice, Myricitrin (10/30 mg/kg, i.p.) blocks apomorphine-induced stereotypy and climbing behaviors, while also prolonging the hindlimb withdrawal time.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antioxidant, Inhibitor, inhibit, Myricetrin, Myricitrin, Myricitrine, PKCα, PKCε

Compound Identifiers

PubChem CID

5281673