Murine TARC protein

• Catalog Number: orb107806
• Category: Proteins
• Description: Thymus and activation regulated chemokine (TARC) is a novel CC chemokine, also called CCL17, recently identified using asignal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (a.a.) residue precursor protein with a 23 a.a.residue signal peptide that is cleaved to generate the 71 a.a. residue mature secreted protein. Among CC chemokine familymembers, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1D, MIP-1E, MCP-1, MCP-2,MCP-3 and I-309. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to bechemotactic for T cell lines but not monocytes or neutrophils. CCL17 was recently identified to be a specific functional ligand forCCR-4, a receptor that is selectively expressed on T cells.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 97% by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 7.9kDa
• Target: TARC
• Protein Sequence: ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKKAIRLVKNPRP
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Alternative names: Murine TARC/CCL17 protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Murine TARC protein