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Murine TARC protein
Catalog Number: orb107806
| Catalog Number | orb107806 |
|---|---|
| Category | Proteins |
| Description | Thymus and activation regulated chemokine (TARC) is a novel CC chemokine, also called CCL17, recently identified using asignal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (a.a.) residue precursor protein with a 23 a.a.residue signal peptide that is cleaved to generate the 71 a.a. residue mature secreted protein. Among CC chemokine familymembers, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1D, MIP-1E, MCP-1, MCP-2,MCP-3 and I-309. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to bechemotactic for T cell lines but not monocytes or neutrophils. CCL17 was recently identified to be a specific functional ligand forCCR-4, a receptor that is selectively expressed on T cells. |
| Target | TARC |
| Conjugation | Unconjugated |
| Buffer/Preservatives | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Purity | > 97% by SDS-PAGE and HPLC analyses |
| Protein Sequence | ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKKAIRLVKNPRP |
| MW | 7.9kDa |
| Tested applications | HPLC, SDS-PAGE |
| Biological Origin | E.coli |
| Storage | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Alternative names | Murine TARC/CCL17 protein |
| Note | For research use only |
SDS-PAGE analysis of Murine TARC protein
