Murine SHH protein

• Catalog Number: orb107802
• Category: Proteins
• Description: Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being deserthedgehog (DHH) and indian hedgehog (IHH). As the hh homologues, SHH has been found to have the most critical roles indevelopment. It acts as a morphogen involved in patterning many systems, including the limb and midline structures in the brain,spinal cord, the thalamus by the zona limitans intrathalamica and the teeth. There SHH undergoes auto-processing to generate a20 kDa (residues 24 - 197) N-terminal signaling domain (SHH-N) and a 25 kDa (residues 198 - 462) C-terminal domain with noknown signaling role.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 19.8 kDa
• Target: SHH
• Protein Sequence: IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKITRNSERFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVKLRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFDWVYYESKAHI HCSVKAENSV AAKSGG
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Alternative names: Murine Sonic Hedgehog protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Murine SHH protein