MTEP hydrochloride

SKU: orb1220389

Description

MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM respectively).(In Vitro):MTEP shows highly selective for mGluR5 over mGluR1, has no effect on other mGluR subtypes, and has fewer off-target effects than MPEP (HY-14609A).(In Vivo):MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.).MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice.

Key Properties

• CAS Number: 1186195-60-7
• MW: 236.72
• Purity: >98% (HPLC)
• Formula: C₁₁H₉ClN₂S
• SMILES: Cc1nc(C#Cc2cccnc2)cs1.Cl
• Target: GluR
• Solubility: H2O:20 mg/mL (84.49 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Male Wistar rats (215-315 g, 5-9/group). Dosage: 1, 3 and 5 mg/kg. Administration: IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.). Result: Inhibited the catalepsy induced by Haloperidol (HY-14538). Animal model: Male C57BL/6J mice (23-25 g). Dosage: 0.3, 1 and 3 mg/kg. Administration: IP, 1 h before the test. Result: Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-((2-Methyl-13-thiazol-4-yl)ethyn-yl)pyridine hydrochloride | MTEP

Quick Database Links

Gene Symbol

GluR