Mouse LY75 / CD205 Protein

• Catalog Number: orb752333
• Category: Proteins
• Description: lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.
• Reactivity: Mouse
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 190.0 kDa
• Target: LY75
• Protein Sequence: NP_038853.2
• Source: Mouse LY75, His Tag (orb752333) is expressed from human 293 cells (HEK293). It contains AA Ser 28 - Asp 1667 (Accession # Q60767-1).
• Expression System: HEK293
• Expression Region: Ser 28 - Asp 1667
• Endotoxins: 1.0 EU per μg
• NCBI: NP_038853.2
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: LY75,CD205,DEC-205,CLEC13B,Lymphocyte antigen 75,g
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 190.0 kDa. The protein migrates as 230-260 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.