Mouse LAIR1 / CD305 Protein

• Catalog Number: orb511329
• Category: Proteins
• Description: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
• Reactivity: Mouse
• Tag: C-mFc(mIgG2a)
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 40.6 kDa
• Target: LAIR-1
• Protein Sequence: NP_001106945.1
• Source: Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (orb511329) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1).
• Expression System: HEK293
• Expression Region: Gln 22 - Tyr 141
• Endotoxins: 0.1 EU per μg
• NCBI: NP_001106945.1
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, pH7.5
• Alternative names: LAIR1,CD305
• Note: For research use only
• Application notes: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.