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Catalog Number | orb383506 |
---|---|
Category | Proteins |
Description | Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
Reactivity | Mouse |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 66.8 kDa |
Target | IL-23R |
Source | Mouse IL-23R, Fc Tag (orb383506) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asp 372 (Accession # Q8K4B4-1). |
Expression System | HEK293 |
Biological Activity | Loaded Mouse IL-23R, Fc Tag on Protein A Biosensor, can bind Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested). |
Expression Region | Gly 24 - Asp 372 |
Endotoxins | 1.0 EU per μg |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 |
Alternative names | IL-23 R,IL-23 Receptor Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 66.8 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse IL-23R protein
Loaded Mouse IL-23R, Fc Tag (Cat. No. orb383506) on Protein A Biosensor, can bind Mouse IL-23A & IL-12B Heterodimer Protein, His Tag & Tag Free with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
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