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Catalog Number | orb257631 |
---|---|
Category | Proteins |
Description | Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development. |
Reactivity | Mouse |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 93.3 kDa |
Target | IL-6 R beta |
Protein Sequence | NP_034690 |
Source | Mouse gp130, Fc Tag (orb257631) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Glu 617 (Accession # NP_034690). |
Expression System | HEK293 |
Expression Region | Gln 23 - Glu 617 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_034690 |
Storage | -20℃ |
Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
Alternative names | IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130 Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 93.3 kDa. The protein migrates as 120-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse gp130 protein
Unconjugated | |
95% | |
68.5 kDa | |
Mouse gp130, His Tag (orb257632) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Glu 617 (Accession # NP_034690). |
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