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Mouse CTLA-4 / CD152 Protein
Catalog Number: orb334893
| Catalog Number | orb334893 |
|---|---|
| Category | Proteins |
| Description | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
| Reactivity | Mouse |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 15.9 kDa |
| Target | CTLA-4 |
| Protein Sequence | NP_033973 |
| Source | Mouse CTLA-4, His Tag (orb334893) is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973). |
| Expression System | HEK293 |
| Expression Region | Glu 36 - Phe 162 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_033973 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | CTLA4,CD152 Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse CTLA-4 protein
- Item 1 of 1
Mouse CTLA-4 / CD152 Protein [orb334892]
Unconjugated
95%
40.6 kDa
Mouse CTLA-4, Fc Tag (orb334892) is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973).
1 mg, 200 μg 
Recombinant Mouse CTLA-4/CD152 Protein, Fc His Tag [orb1550826]
> 95% by SDS-PAGE.
KMP1663, Recombinant Mouse CTLA-4/CD152 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Ala37-Asp161) of mouse CTLA-4/CD152 (Accession #P09793) fused with an Fc tag at the C-terminus.
500 μg, 50 μgRecombinant Mouse CTLA-4/CD152 Protein, His Tag [orb1550298]
> 95% by SDS-PAGE.
KMP2191, Recombinant Mouse CTLA-4/CD152 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Glu36-Asp161) of Mouse CTLA4 (Accession #NP_033973.2) fused with an 6×His Tag at the C-terminus.
50 μg, 100 μgRecombinant Mouse Ctla-4/CD152 Protein, His Tag [orb1552603]
≥90% as determined by SDS-PAGE
This protein contains the mouse Ctla4(Ala37-Asp161) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Mouse Ctla-4/CD152 Protein, Flag Tag [orb1552605]
≥90% as determined by SDS-PAGE
This protein contains the mouse Ctla4(Ala37-Asp161) was fused with the C-terminus Flag Tag and expressed in Mammalian cells.
100 μg, 50 μg
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