Mouse CLEC12A / MICL / CLL-1 Protein

• Catalog Number: orb735038
• Category: Proteins
• Description: CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
• Reactivity: Mouse
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 25.7 kDa
• Target: CLEC12A
• Protein Sequence: Tyr 65 - Arg 267
• Source: Mouse CLEC12A, His Tag (orb735038) is expressed from human 293 cells (HEK293). It contains AA Tyr 65 - Arg 267 (Accession # Q504P2-1).
• Expression System: HEK293
• Expression Region: Tyr 65 - Arg 267
• Endotoxins: 1.0 EU per μg
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 25.7 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.