Mouse CD47 Protein

More Information
Category	Proteins
Catalog Number	orb511323
Reactivity	Mouse
Conjugation	Unconjugated
MW	15.7 kDa
Target	CD47
Protein Sequence	XP_006521874.1
Tag	C-10×His
Source	Mouse CD47, His Tag (CD7-M522b) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Lys 140 (Accession # Q61735-1).
Biological origin	Mouse
Storage	-20℃
Purity	90%
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH7.4
Endotoxin	1.0 EU per μg
Note	For research use only.
Expiration Date	6 months from date of receipt.
Description	Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.